Bayesian inference assessment of protein secondary structure analysis using circular dichroism data – how much structural information is contained in protein circular dichroism spectra?

Circular Dichroism of Protein

Computation and analysis of protein circular dichroism spectra.

Introduction Circular dichroism (CD) is the most widely used form of chiroptical spectroscopy, spectroscopic techniques that utilize the differential interaction of molecules with left− and right−circularly polarized light. In the absence of a magnetic field, the molecule must be chiral to give rise to a difference in the interaction with the two types of circularly polarized light. The phenome...

On the analysis of membrane protein circular dichroism spectra.

Analysis of circular dichroism spectra of proteins provides information about protein secondary structure. Analytical methods developed for such an analysis use structures and spectra of a set of reference proteins. The reference protein sets currently in use include soluble proteins with a wide range of secondary structures, and perform quite well in analyzing CD spectra of soluble proteins. T...

DICHROWEB: an interactive website for the analysis of protein secondary structure from circular dichroism spectra

A user-friendly website for the analysis of protein secondary structures from Circular Dichroism (CD) and Synchrotron Radiation Circular Dichroism (SRCD) spectra has been created.

Estimation of protein secondary structure and error analysis from circular dichroism spectra.

The estimation of protein secondary structure from circular dichroism spectra is described by a multivariate linear model with noise (Gauss-Markoff model). With this formalism the adequacy of the linear model is investigated, paying special attention to the estimation of the error in the secondary structure estimates. It is shown that the linear model is only adequate for the alpha-helix class....